Dr. Francesco Fontani, U. Bologna "A search for high-mass pre-stellar cores" Abstract: The initial conditions of the high-mass star formation process are still poorly understood. I will present a work in which we have measured deuterium fractionation and CO depletion factor (the ratio between expected and observed CO abundance) in a sample of high-massprotostellar candidates, in order to understand whether the earliest evolutionary stages of massive stars have chemical characteristics similar to those of low-mass ones. We have detected N2D+ emission in 7 of the 10 sources of our sample, and found values of deuterium fractionation nearly 3 orders of magnitude larger than the cosmic D/H abundance, but lower than those found in low-mass pre-stellar cores. Given the low angular resolution of the data, the cold gas that generates the N2D+ emission in principle can be distibuted in the extended envelope of the massive protostellar object, or concentrated into one (or more) pre-stellar cores located close to it. Higher angular resolution observations will be very helpful in deciding which solution is correct. I will also show some recent SMA observations performed towards IRAS05345+3157, one of the sources of the initial sample that stands out from the rest for its interesting characteristics.